ea0044p47 | Bone and Calcium | SFEBES2016
Gorvin Caroline
, Babinsky Valerie
, Schou Anders
, Nissen Peter
, Hannan Fadil
, Thakker Rajesh
The CaSR, a G-protein-coupled receptor that regulates extracellular calcium (Ca2+o), predominantly signals via G-protein-αq/11 (Gαq/11), initiating IP3-mediated intracellular calcium (Ca2+i) accumulation, and mitogen-activated protein kinase (MAPK) signalling. CaSR also activates MAPK signalling via Gαi/o, or by associating with the scaffolding protein β-arrestin. CaSR g...